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Motif ID: TFAP2{A,C}.p2

Z-value: 2.372

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr17_-_74707000	6.227	NM_001008528 NM_001008529 NM_198530	MXRA7	matrix-remodelling associated 7
chr2_-_224903933	5.148	NM_001136528 NM_006216	SERPINE2	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
chr11_-_65640199	5.004	NM_016938	EFEMP2	EGF containing fibulin-like extracellular matrix protein 2
chr1_-_85930610	4.711		DDAH1	dimethylarginine dimethylaminohydrolase 1
chr3_-_185542807	4.419	NM_001007225 NM_006548	IGF2BP2	insulin-like growth factor 2 mRNA binding protein 2
chr2_-_20212408	4.297		MATN3	matrilin 3
chr15_-_48937068	4.005		FBN1	fibrillin 1
chr12_-_106641675	3.960	NM_006825	CKAP4	cytoskeleton-associated protein 4
chr6_+_107811272	3.856	NM_018013	SOBP	sine oculis binding protein homolog (Drosophila)
chr6_+_151561653	3.801		AKAP12	A kinase (PRKA) anchor protein 12
chr8_-_48650683	3.596		CEBPD	CCAAT/enhancer binding protein (C/EBP), delta
chr19_-_18717467	3.560		CRLF1	cytokine receptor-like factor 1
chr17_-_74707066	3.403		MXRA7	matrix-remodelling associated 7
chr3_-_124774735	3.341	NM_020733	HEG1	HEG homolog 1 (zebrafish)
chr19_-_18717631	3.317	NM_004750	CRLF1	cytokine receptor-like factor 1
chr9_+_137533643	3.296	NM_000093	COL5A1	collagen, type V, alpha 1
chr3_-_149688638	3.223	NM_002628 NM_053024	PFN2	profilin 2
chr13_+_98795710	3.137		FARP1	FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
chr19_-_18717577	3.073		CRLF1	cytokine receptor-like factor 1
chr7_-_45960738	2.966	NM_000598 NM_001013398	IGFBP3	insulin-like growth factor binding protein 3
chr3_-_149688886	2.955		PFN2	profilin 2
chr2_-_224903324	2.901	NM_001136530	SERPINE2	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
chr3_-_45267068	2.899		TMEM158	transmembrane protein 158 (gene/pseudogene)
chr1_-_85930733	2.897	NM_012137	DDAH1	dimethylarginine dimethylaminohydrolase 1
chr2_+_173292344	2.798		ITGA6	integrin, alpha 6
chr3_-_129325175	2.749	NM_015103	PLXND1	plexin D1
chr2_+_241375030	2.683	NM_002081	GPC1	glypican 1
chr13_+_27131879	2.670		WASF3	WAS protein family, member 3
chr10_+_104404195	2.665	NM_030912	TRIM8	tripartite motif containing 8
chr8_+_22436641	2.629		PDLIM2	PDZ and LIM domain 2 (mystique)
chr6_+_151561508	2.551		AKAP12	A kinase (PRKA) anchor protein 12
chr8_-_48650703	2.544	NM_005195	CEBPD	CCAAT/enhancer binding protein (C/EBP), delta
chr9_+_133320093	2.541	NM_000050 NM_054012	ASS1	argininosuccinate synthase 1
chr2_-_218843541	2.534		TNS1	tensin 1
chr2_+_235860616	2.533	NM_014521	SH3BP4	SH3-domain binding protein 4
chr2_+_36583369	2.529	NM_016441	CRIM1	cysteine rich transmembrane BMP regulator 1 (chordin-like)
chr2_-_20212448	2.528	NM_002381	MATN3	matrilin 3
chr12_-_15942350	2.494	NM_004447	EPS8	epidermal growth factor receptor pathway substrate 8
chrX_-_34675366	2.474	NM_031442	TMEM47	transmembrane protein 47
chr16_-_4166185	2.433	NM_001116	ADCY9	adenylate cyclase 9
chr20_-_50384861	2.403		ATP9A	ATPase, class II, type 9A
chr2_-_158732341	2.403	NM_001111067	ACVR1	activin A receptor, type I
chr5_+_92920592	2.373		NR2F1 NR2F2	nuclear receptor subfamily 2, group F, member 1 nuclear receptor subfamily 2, group F, member 2
chr3_-_45267620	2.355		TMEM158	transmembrane protein 158 (gene/pseudogene)
chr5_+_34656482	2.347		RAI14	retinoic acid induced 14
chr12_-_77272767	2.328	NM_001321	CSRP2	cysteine and glycine-rich protein 2
chr1_-_33168356	2.325	NM_001161708 NM_030786	SYNC	syncoilin, intermediate filament protein
chr15_+_74218962	2.211		LOXL1	lysyl oxidase-like 1
chr12_-_124457099	2.209	NM_025140	CCDC92	coiled-coil domain containing 92
chr5_+_34656367	2.203	NM_001145522 NM_015577	RAI14	retinoic acid induced 14
chr22_-_36424397	2.194	NM_001082578 NM_001082579	RBFOX2	RNA binding protein, fox-1 homolog (C. elegans) 2
chr2_+_236402685	2.191	NM_001037131 NM_001244888 NM_014914	AGAP1	ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
chr5_+_34656595	2.159	NM_001145520	RAI14	retinoic acid induced 14
chr6_-_138428477	2.124	NM_022121	PERP	PERP, TP53 apoptosis effector
chr5_-_172755418	2.094		STC2	stanniocalcin 2
chr6_-_128841432	2.086	NM_002844 NM_001135648	PTPRK	protein tyrosine phosphatase, receptor type, K
chr17_-_76921076	2.083		TIMP2	TIMP metallopeptidase inhibitor 2
chr1_-_156647088	2.053	NM_006617	NES	nestin
chr9_+_133320247	2.044		ASS1	argininosuccinate synthase 1
chr2_-_183902747	2.041		NCKAP1	NCK-associated protein 1
chr10_+_124134206	2.038		PLEKHA1	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr2_-_73340058	2.016		RAB11FIP5	RAB11 family interacting protein 5 (class I)
chr7_-_111846384	1.997	NM_014705	DOCK4	dedicator of cytokinesis 4
chr17_+_74864427	1.992	NM_001199172 NM_144677	MGAT5B	mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B
chr11_+_12695851	1.990	NM_021961	TEAD1	TEA domain family member 1 (SV40 transcriptional enhancer factor)
chr12_-_15942116	1.967		EPS8	epidermal growth factor receptor pathway substrate 8
chr2_+_173292306	1.963	NM_000210 NM_001079818	ITGA6	integrin, alpha 6
chr9_-_88714460	1.940		GOLM1	golgi membrane protein 1
chr17_-_76921205	1.931		TIMP2	TIMP metallopeptidase inhibitor 2
chr15_+_81071708	1.924	NM_018689	KIAA1199	KIAA1199
chr15_+_33010174	1.918	NM_001191322 NM_001191323 NM_013372	GREM1	gremlin 1
chr20_+_45338125	1.892	NM_030777	SLC2A10	solute carrier family 2 (facilitated glucose transporter), member 10
chr2_-_73339911	1.877		RAB11FIP5	RAB11 family interacting protein 5 (class I)
chr20_-_60942300	1.877	NM_005560	LAMA5	laminin, alpha 5
chr15_-_90358057	1.871	NM_001150	ANPEP	alanyl (membrane) aminopeptidase
chr2_-_175869910	1.830	NM_001822 NM_001025201	CHN1	chimerin (chimaerin) 1
chr4_-_22517339	1.819	NM_145290	GPR125	G protein-coupled receptor 125
chr15_+_96873845	1.814	NM_021005	NR2F2	nuclear receptor subfamily 2, group F, member 2
chr8_+_30241943	1.813	NM_001008710 NM_001008711 NM_001008712 NM_006867	RBPMS	RNA binding protein with multiple splicing
chr5_-_39424930	1.794		DAB2	disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr3_+_187871473	1.791	NM_001167672	LPP	LIM domain containing preferred translocation partner in lipoma
chr20_-_50384899	1.782	NM_006045	ATP9A	ATPase, class II, type 9A
chr9_-_94186140	1.774	NM_005384	NFIL3	nuclear factor, interleukin 3 regulated
chr4_-_1166364	1.763		SPON2	spondin 2, extracellular matrix protein
chr9_-_35689902	1.743	NM_003289 NM_213674	TPM2	tropomyosin 2 (beta)
chr6_-_52441815	1.741	NM_012288	TRAM2	translocation associated membrane protein 2
chr4_-_57976355	1.739		IGFBP7	insulin-like growth factor binding protein 7
chr10_-_17659365	1.734	NM_014241	PTPLA	protein tyrosine phosphatase-like (proline instead of catalytic arginine), member A
chr22_+_33197744	1.726		TIMP3	TIMP metallopeptidase inhibitor 3
chr2_-_73340073	1.709	NM_015470	RAB11FIP5	RAB11 family interacting protein 5 (class I)
chr14_-_30396811	1.708	NM_002742	PRKD1	protein kinase D1
chr3_+_37903643	1.703	NM_001008392 NM_005808	CTDSPL	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
chr8_+_37654406	1.700		GPR124	G protein-coupled receptor 124
chr5_-_39425030	1.671		DAB2	disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr13_+_27131799	1.667	NM_006646	WASF3	WAS protein family, member 3
chr13_-_107187312	1.663	NM_004093	EFNB2	ephrin-B2
chr6_+_7541892	1.663		DSP	desmoplakin
chr9_-_94185959	1.661		NFIL3	nuclear factor, interleukin 3 regulated
chr20_-_43977023	1.635	NM_002999	SDC4	syndecan 4
chr19_+_33685489	1.635	NM_002333	LRP3	low density lipoprotein receptor-related protein 3
chr8_-_131455833	1.632	NM_001247996 NM_018482	ASAP1	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
chr3_-_185542744	1.625		IGF2BP2	insulin-like growth factor 2 mRNA binding protein 2
chr9_-_88714486	1.620	NM_016548	GOLM1	golgi membrane protein 1
chr20_+_44519590	1.619	NM_000308 NM_001127695 NM_001167594	CTSA	cathepsin A
chrX_-_133119475	1.607		GPC3	glypican 3
chr2_+_113403433	1.603	NM_005415	SLC20A1	solute carrier family 20 (phosphate transporter), member 1
chr1_-_33815411	1.585		PHC2	polyhomeotic homolog 2 (Drosophila)
chr5_-_121414011	1.578	NM_002317	LOX	lysyl oxidase
chr17_-_46115135	1.573	NM_016429	COPZ2	coatomer protein complex, subunit zeta 2
chr11_+_12132063	1.558	NM_014632	MICAL2	microtubule associated monoxygenase, calponin and LIM domain containing 2
chr17_-_5404304	1.557	NM_001162371	LOC728392	uncharacterized LOC728392
chr14_-_75078669	1.556	NM_000428	LTBP2	latent transforming growth factor beta binding protein 2
chr5_+_72921980	1.548	NM_001080479 NM_001177693	RGNEF	190 kDa guanine nucleotide exchange factor
chr10_+_124134093	1.547	NM_001001974	PLEKHA1	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr16_-_4166021	1.547		ADCY9	adenylate cyclase 9
chr5_-_39425297	1.542	NM_001244871 NM_001343	DAB2	disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr12_-_105629790	1.537	NM_001251904 NM_018171	APPL2	adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
chr4_+_4861371	1.536	NM_002448	MSX1	msh homeobox 1
chr10_-_79686279	1.532	NM_004747	DLG5	discs, large homolog 5 (Drosophila)
chr5_-_121413967	1.521		LOX	lysyl oxidase
chr10_+_124220990	1.520	NM_002775	HTRA1	HtrA serine peptidase 1
chr4_-_1166378	1.518		SPON2	spondin 2, extracellular matrix protein
chr6_+_148663953	1.512		SASH1	SAM and SH3 domain containing 1
chr6_-_132272311	1.502	NM_001901	CTGF	connective tissue growth factor
chr4_-_1166458	1.501		SPON2	spondin 2, extracellular matrix protein
chr8_-_12990731	1.499	NM_006094	DLC1	deleted in liver cancer 1
chr12_-_106532447	1.498		NUAK1	NUAK family, SNF1-like kinase, 1
chr11_+_86511490	1.493	NM_007173	PRSS23	protease, serine, 23
chr20_+_11871364	1.488	NM_181443	BTBD3	BTB (POZ) domain containing 3
chr11_+_129940462	1.487	NM_001243299	APLP2	amyloid beta (A4) precursor-like protein 2
chr10_+_123922940	1.476		TACC2	transforming, acidic coiled-coil containing protein 2
chr11_-_2950593	1.476	NM_003311	PHLDA2	pleckstrin homology-like domain, family A, member 2
chr15_+_74218811	1.474		LOXL1	lysyl oxidase-like 1
chr11_+_129939792	1.459		APLP2	amyloid beta (A4) precursor-like protein 2
chr19_+_15218141	1.457	NM_033025	SYDE1	synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
chr12_-_123756164	1.454	NM_004642	CDK2AP1	cyclin-dependent kinase 2 associated protein 1
chr6_-_52441714	1.451		TRAM2	translocation associated membrane protein 2
chr12_-_110318178	1.451	NM_016433	GLTP	glycolipid transfer protein
chr13_-_110959441	1.447	NM_001845	COL4A1	collagen, type IV, alpha 1
chr2_-_55277421	1.446		RTN4	reticulon 4
chrX_+_117861523	1.442	NM_001560	IL13RA1	interleukin 13 receptor, alpha 1
chr14_-_25519076	1.441	NM_014178	STXBP6	syntaxin binding protein 6 (amisyn)
chr13_-_45150601	1.431	NM_001243799 NM_183422	TSC22D1	TSC22 domain family, member 1
chr9_-_84303595	1.424	NM_005077	TLE1	transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
chr21_-_28217272	1.420		ADAMTS1	ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr18_-_25757351	1.416	NM_001792	CDH2	cadherin 2, type 1, N-cadherin (neuronal)
chr17_-_76921453	1.405	NM_003255	TIMP2	TIMP metallopeptidase inhibitor 2
chr3_-_32022734	1.403		OSBPL10	oxysterol binding protein-like 10
chr21_+_18885296	1.391		CXADR	coxsackie virus and adenovirus receptor
chr10_-_126849066	1.377	NM_001329	CTBP2	C-terminal binding protein 2
chr3_+_51428720	1.373		RBM15B	RNA binding motif protein 15B
chr5_-_57755787	1.372	NM_001252226 NM_006622	PLK2	polo-like kinase 2
chrX_+_135229536	1.367	NM_001159702 NM_001159703 NM_001449	FHL1	four and a half LIM domains 1
chr11_+_832909	1.364	NM_001039490 NM_004357 NM_139029 NM_139030	CD151	CD151 molecule (Raph blood group)
chr4_-_177713664	1.360	NM_005429	VEGFC	vascular endothelial growth factor C
chr22_+_33197678	1.358		TIMP3	TIMP metallopeptidase inhibitor 3
chr9_-_113800243	1.352	NM_001401 NM_057159	LPAR1	lysophosphatidic acid receptor 1
chr6_+_146864827	1.348	NM_006834	RAB32	RAB32, member RAS oncogene family
chr8_+_37654757	1.347		GPR124	G protein-coupled receptor 124
chr5_-_16936371	1.347	NM_012334	MYO10	myosin X
chr17_-_3571819	1.343		TAX1BP3	Tax1 (human T-cell leukemia virus type I) binding protein 3
chr13_+_110959592	1.337	NM_001846	COL4A2	collagen, type IV, alpha 2
chr15_+_67358194	1.332	NM_005902	SMAD3	SMAD family member 3
chrX_-_133119624	1.323	NM_001164617 NM_001164618 NM_001164619 NM_004484	GPC3	glypican 3
chr17_-_79818514	1.322	NM_000918	P4HB	prolyl 4-hydroxylase, beta polypeptide
chr16_-_52580805	1.320	NM_001080430	TOX3	TOX high mobility group box family member 3
chr4_-_57976516	1.315		IGFBP7	insulin-like growth factor binding protein 7
chr9_-_88714395	1.314		GOLM1	golgi membrane protein 1
chr12_+_26348268	1.308	NM_001135823	SSPN	sarcospan (Kras oncogene-associated gene)
chr11_-_66084501	1.301	NM_020404	CD248	CD248 molecule, endosialin
chr11_+_117070039	1.300	NM_001001522 NM_003186	TAGLN	transgelin
chr7_-_107643330	1.294	NM_002291	LAMB1	laminin, beta 1
chr1_-_120612301	1.290	NM_001200001 NM_024408	NOTCH2	notch 2
chr10_+_28966419	1.288	NM_012342	BAMBI	BMP and activin membrane-bound inhibitor homolog (Xenopus laevis)
chr8_+_136469557	1.286	NM_006558	KHDRBS3	KH domain containing, RNA binding, signal transduction associated 3
chr2_-_55277459	1.279		RTN4	reticulon 4
chr1_+_111415791	1.272		CD53	CD53 molecule
chr2_-_55277592	1.263		RTN4	reticulon 4
chr8_-_62627111	1.262		ASPH	aspartate beta-hydroxylase
chr22_-_29075708	1.258	NM_001145418	TTC28	tetratricopeptide repeat domain 28
chr4_-_102268333	1.244		PPP3CA	protein phosphatase 3, catalytic subunit, alpha isozyme
chr1_+_111415721	1.243	NM_000560	CD53	CD53 molecule
chr15_+_80696569	1.242	NM_014862	ARNT2	aryl-hydrocarbon receptor nuclear translocator 2
chr5_-_111093792	1.237	NM_001142477 NM_001142476	C5orf13	chromosome 5 open reading frame 13
chr4_-_2263808	1.236		MXD4	MAX dimerization protein 4
chr1_+_20959946	1.235	NM_032409	PINK1	PTEN induced putative kinase 1
chr11_+_129939807	1.235		APLP2	amyloid beta (A4) precursor-like protein 2
chr3_+_171758289	1.234	NM_001135095	FNDC3B	fibronectin type III domain containing 3B
chr6_+_1390068	1.229	NM_001452	FOXF2	forkhead box F2
chr22_+_38201113	1.219	NM_005318	H1F0	H1 histone family, member 0
chr19_+_35521591	1.214	NM_001037 NM_199037	SCN1B	sodium channel, voltage-gated, type I, beta
chr11_+_129939787	1.214		APLP2	amyloid beta (A4) precursor-like protein 2
chr10_+_71812536	1.211		H2AFY2	H2A histone family, member Y2
chr4_+_88928797	1.210	NM_000297	PKD2	polycystic kidney disease 2 (autosomal dominant)
chr8_+_37654833	1.203		GPR124	G protein-coupled receptor 124
chr1_+_19970674	1.198	NM_005380	NBL1	neuroblastoma, suppression of tumorigenicity 1
chr11_+_19734821	1.196	NM_001244963 NM_145117 NM_182964	NAV2	neuron navigator 2
chr22_+_22735134	1.194		CYAT1	immunoglobulin lambda light chain-like
chr10_-_33247131	1.194		ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
chr15_-_48937795	1.192	NM_000138	FBN1	fibrillin 1

Gene overrepresentation in process category:

Enrichment	P-value	GO Accession	GO Term
2.58	1.16e-06	GO:0009653	anatomical structure morphogenesis
1.92	4.61e-06	GO:0048856	anatomical structure development
4.00	6.46e-06	GO:0072358	cardiovascular system development
4.00	6.46e-06	GO:0072359	circulatory system development
1.95	1.51e-05	GO:0048731	system development
1.76	3.58e-05	GO:0032502	developmental process
1.79	8.47e-05	GO:0007275	multicellular organismal development
7.32	2.59e-04	GO:0090092	regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
2.71	7.82e-04	GO:0040011	locomotion
4.24	1.10e-03	GO:0001944	vasculature development
3.56	1.52e-03	GO:0016477	cell migration
3.02	2.06e-03	GO:0032989	cellular component morphogenesis
4.26	2.22e-03	GO:0001568	blood vessel development
3.04	3.02e-03	GO:0000902	cell morphogenesis
3.31	4.47e-03	GO:0048870	cell motility
3.31	4.47e-03	GO:0051674	localization of cell
4.49	6.05e-03	GO:0048514	blood vessel morphogenesis
2.16	7.00e-03	GO:0009966	regulation of signal transduction
1.91	8.07e-03	GO:0048869	cellular developmental process
1.49	1.07e-02	GO:0032501	multicellular organismal process
3.09	1.19e-02	GO:0048858	cell projection morphogenesis
4.97	1.21e-02	GO:0001525	angiogenesis
3.08	1.23e-02	GO:0000904	cell morphogenesis involved in differentiation
3.06	1.37e-02	GO:0032990	cell part morphogenesis
5.23	1.90e-02	GO:0034330	cell junction organization
1.88	2.08e-02	GO:0030154	cell differentiation
2.05	2.24e-02	GO:0007399	nervous system development
6.13	4.14e-02	GO:0030198	extracellular matrix organization
1.86	4.26e-02	GO:0048513	organ development
3.17	4.28e-02	GO:0009968	negative regulation of signal transduction

Gene overrepresentation in compartment category:

Enrichment	P-value	GO Accession	GO Term
5.57	5.18e-10	GO:0031012	extracellular matrix
5.38	1.63e-07	GO:0005578	proteinaceous extracellular matrix
11.36	2.54e-06	GO:0005604	basement membrane
7.40	4.68e-05	GO:0044420	extracellular matrix part
2.45	5.80e-04	GO:0044421	extracellular region part
4.49	1.43e-02	GO:0070161	anchoring junction
3.05	2.33e-02	GO:0009986	cell surface
4.50	3.20e-02	GO:0005912	adherens junction
1.81	3.22e-02	GO:0005576	extracellular region
1.69	3.62e-02	GO:0044459	plasma membrane part

Gene overrepresentation in function category:

Enrichment	P-value	GO Accession	GO Term
19.77	7.27e-05	GO:0005520	insulin-like growth factor binding
8.72	1.61e-04	GO:0005201	extracellular matrix structural constituent
6.53	5.94e-04	GO:0019838	growth factor binding
1.33	2.90e-03	GO:0005515	protein binding